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PUBLICATIONS of David S. Howell, M.D. ____________________________________________________________________________
Books, Monographs, Book Chapters, and Videotapes
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Books, Monographs, Book Chapters, and Videotapes: 1. Howell, D.S. Fibrin-like substances in collagen-vascular disease. Chapter 1. In: Progress in Arthritis. Talbott, J.H., Lockie, L.M., eds. New York, Grune and Stratton, 1958. pp. 1-21.
2. Howell, D.S. Hypertrophic osteoarthropathy and developmental connective tissue disorders. Chapter 63. In: Arthritis and Allied Conditions. 6 th ed. Hollander, J.L., et al, eds. Philadelphia, Lea and Febiger, 1960. pp. 1056-71.
3. Howell, D.S. Metabolic bone diseases. Chapter 53. In: Arthritis and Allied Conditions. 6 th ed. Hollander, J.L., et al, eds. Philadelphia, Lea and Febiger, 1960. pp. 907-26.
4. Howell, D.S. Characterization of a fluid phase at calcifying sites of epiphyseal cartilage in experimental rickets. In: Conference on Biology of Hard Tissue, Pacific Palisades, CA, March, 1966. New York, Gordon and Breach, 1966. pp. 85-8.
5. Howell, D.S. The fate of sulfated compounds in calcifying cartilage septa, studied by x-ray elemental analysis for sulfur and phosphorous at microscopic sites. In: Cartilage Degradation and Repair; Proceedings of a Workshop, 1966. Bassett, C.A.L., ed. Washington, D.C., National Research Council, 1967. pp. 50-3.
6. Howell, D.S., Carlson, L. Utilization of x-ray elemental analysis for sulfur to study metabolism of sulfate at calcifying sites. In: Symposium, Optique des Rayons X et Microanalyse. Cosslett, V.E., Engstrom, A., eds. Paris, Hermann, 1967. pp. 664-8.
7. Howell, D.S. Partition of proteinpolysaccharides on calcifying sites. In: Symposium on Biology of Hard Tissues, 6 th, Pacific Palidades, CA, 1969. New York Academy of Sciences and Smithsonian Institution, 1969. pp. 90-3.
8. Howell, D.S., Pita, J.C., Marquez, J.F., Muller, F.J., Padro, V. Evidence for a proteinpolysaccharide complex (PPC) inhibitor and a mineral nucleator in micropuncture fluids (CFL) from calcifying cartilage. In: Proceedings of the International Symposium on Biochemistry and Physiology of Connective Tissue, Lyon, 1966. Comte, P., ed. Prague, CZ, Geoindustria, 1969. pp. 176.
9. Howell, D.S. Metabolic bone diseases. Chapter 62. In: Arthritis and Allied Conditions. 8 th ed. Hollander, J.L., McCarty, D.J., Jr., et al, eds. Philadelphia, Lea & Febiger, 1972. pp. 1178-99.
10. Howell, D.S. Hypertrophic osteoarthropathy. Chapter 74. In: Arthritis and Allied Conditions. 8 th ed. Hollander, J.L., McCarty, D.J., Jr., et al, eds. Philadelphia, Lea & Febiger, 1972. pp. 1367-73.
11. Thomas, L., Christian, C.L., Decker, J.L., Howell, D.S., et al. New Directions in Arthritis Research. New York, Arthritis Foundation, 1973.
12. Howell, D.S., Muniz, O., and Pita, J.C. Extrusion of pyrophosphate into extracellular media by cartilage incubates. In: Symposium on Normal and Osteoarthritic Articular Cartilage, London, 1973. Proceedings. Ali, S.Y., Elves, M.W., Leaback, D.H., eds. Stanmore, Institute of Orthopaedics, University of London, 1974. pp. 177-87.
13. Howell, D.S. Osteoarthritis (degenerative joint disease). In: Current Diagnosis. 4th ed. Conn, H.F., Conn, R.B., Jr., eds. Philadelphia, Saunders, 1974. pp. 743-5.
14. Howell, D.S. Osteoarthritis. In: Current Therapy. 26th ed. Conn, H.F., ed. Philadelphia, Saunders, 1974. pp. 743-4.
15. Pita, J.C., Muller, F., Howell, D.S. Disaggregation of proteoglycan aggregate during endochondral calcification: physiological role of cartilage lysozyme. In: Symposium on Dynamics of Connective Tissue Macromolecules, Cambridge, Eng., 1974. New York, Elsevier, 1974. pp. 247-58.
16. Pita, J.C., Howell, D.S., Kuettner, K.E. Evidence for a role of lysozyme in endochondral calcification during healing of rickets. In: Santa Catalina Island Colloquium, 2d, 1974. Extracellular Matrix Influences on Gene Expression; Proceedings. Slavkin, H.C., Greulich, R.C., eds. New York, Academic Press, 1975. pp. 721-6.
17. Kuettner, K.E., Pita, J.C., Howell, D.S., Sorgente, N., Eisenstein, R. Regulation of epiphyseal cartilage maturation. In: Santa Catalina Island Colloquium, 2d, 1974. Extracellular Matrix Influences on Gene Expression; Proceedings. Slavkin, H.C., Greulich, R.C., eds. New York, Academic Press, 1975. pp. 435-40.
18. Howell, D.S., Pita, J.C., Kuettner, K.E. Evidence for a role of lysozyme in endochondral calcification. In: Calcium Metabolism, Bone and Metabolic Bone Diseases. Kuhlencordt, F., Kruse, H.-P., eds. New York, Springer-Verlag, 1975. p. 189.
19. Sapolsky, A.I., Woessner, J.F., Jr., Howell, D.S. Neutral and acid metalloproteinases in human articular cartilage which degrade proteoglycan. In: Proteolysis and Physiological Regulation; Miami Winter Symposium, vol. 11. Ribbons, D.W., Brew, K., eds. New York, Academic Press, 1976. p. 404.
20. Howell, D.S., Sapolsky, A.I., Pita, J.C. The Pathogenesis of Degenerative Joint Disease. Kalamazoo, MI, UpJohn Company, 1976. 28 pp.
21. Howell, D.S. Osteoarthritis—etiology and pathogenesis. In: Symposium on Osteoarthritis, Chicago, 1974. St. Louis, Mosby, 1976. pp. 44-7.
22. Pita, J.C., Howell, D.S. Microbiochemical studies of cartilage. Chapter 7. In: The Joints and Synovial Fluid. Sokoloff, L., ed. New York, Academic Press, 1978. pp. 273-324.
23. Howell, D.S., Altman, R.D. Management of osteoarthritis. In: Continuing Education for the Family Physician, May, 1978. pp. 53-5, 61-3.
24. Howell, D.S., Woessner, J.F., Jr., Sapolsky, A.I. Enzymes in degenerative joint disease and antienzyme therapy. Chapter 15. In: The Human Joint in Health and Disease. Simon, W.H., ed. Philadelphia, University of Pennsylvania Press, 1978. p. 128-131.
25. Howell, D.S. Psoriatic arthritis, pp. 71-4; Felty's syndrome, pp. 75-6; Osteoarthritis, pp. 155-63; Low backache, pp. 164-6; Chondrocalcinosis, pp. 173-5. In: Clinical Rheumatology. Talbott, J.H., ed. New York, Elsevier, 1978.
26. Anderson, H.C., Howell, D.S., guest eds. Second Conference on Matrix Vesicle Calcification, SUNY, Purchase, New York, June 11-15, 1978. Metab. Bone Dis. Rel. Res. 1:83-242, 1978.
27. Pita, J.C., Muller, F.J., Howell, D.S. Structural changes of sulfated proteoglycans of rat growth cartilage during endochondral calcification. In: Proceedings of the Fourth International Symposium on Glycoconjugates Research. Gregory, J., Jeanloz, R.W., eds. New York, Academic Press, 1979. pp. 743-6.
28. Howell, D.S. Hypertrophic osteoarthropathy. Chapter 63; Biochemical studies of osteoarthritis. Chapter 74; Metabolic bone diseases. Chapter 82. In: Arthritis and Allied Conditions. 9 th ed. McCarty, D.J., ed. Philadelphia, Lea and Febiger, 1979. pp. 977-82, 1154-60 & 1300-17.
29. Howell, D.S. Osteoarthritis: speculations on some biochemical factors of possible aetiological nature including cartilage mineralization. In: The Aetiopathogenesis of Osteoarthrosis. Nuki, G., ed. Kent, Eng., Pitman Medical, 1980. pp. 93-104.
30. Woessner, J.F., Jr., Howell, D.S. The enzymatic degradation of connective tissue matrices. In: Scientific Foundation of Orthopaedics and Traumatology, Owen, R., Goodfellow, J., Bullough, P., eds. London, Heinemann, 1980. pp. 232-41.
31. Howell, D.S. Aging in osteoarthritis: osteoarthrosis of degenerative joint disease. In: Aging, Immunity and Arthritic Disease, Vol. II. Kay, M.M.B., Galpin, J., Makinodan, T., eds. New York, Raven Press, 1980. pp. 135-50.
32. Talbott, J.H., Howell, D.S., eds. Osteoarthritis Symposium, Palm Aire, FL, October, 1980. New York, Grune & Stratton, 1981. 149 p. (Seminars in Arthritis and Rheumatism, Vol. 11, No. 1, Suppl. 1)
33. Howell, D.S. Diseases due to the deposition of calcium pyrophosphate and hydroxyapatite. In: Textbook of Rheumatology. Kelley, W.N., Harris, E.D., Jr., Ruddy, S., Sledge, C.B., eds. Philadelphia, Saunders, 1981. pp. 1438-54.
34. Howell, D.S., Muniz, O.E., Morales, S.M. 5'Nucleotidase and pyrophosphate (PPi)-generating activities in articular cartilage extracts in calcium pyrophosphate deposition disease (CPDD) and in primary osteoarthritis (OA). In: Epidemiology of Osteoarthritis. Peyron, J., ed. Paris, Ciba-Geigy, 1981. pp. 99-108.
35. Howell, D.S. Pathogenesis of osteoarthritis: some clinical and basic aspects. In: Proceedings of the Symposium on Osteoarthritis, Aarhus, Denmark, 1979. Gylding-Sabroe, J.P., ed. 1981. p. 10.
36. Pita, J.C., Blanco, L.N., Drabin, S.A., Larsson, A., Howell, D.S. Calcification inductors: a comparison of nucleational agents in growth cartilage fluid and in predentin. In: Proceedings of the First International Conference on the Chemistry and Biology of Mineralized Connective Tissues, Chicago, 1981. Veis, A., ed. Chicago, Elsevier North Holland, 1981. pp. 289-92.
37. Woessner, J.F., Howell, D.S., eds. Hydrolytic enzymes in cartilage. Studies in Joint Disease, 2:4-152, 1981.
38. Howell, D.S., Pita, J.C., Woessner, J.F. Biochemical changes in cartilage relevant to the cause and management of osteoarthritis. Chapter 2. In: New Trends in Osteoarthritis. Huskisson, E.C., Katona, G., eds. Basel, Karger, 1982. pp. 29-45.
39. Howell, D.S.: Osteoarthritis. Chapter 9. In: Clinical Trends in Orthopaedics. Straub, L.R., Wilson, P.D., Jr., eds. New York, Thieme-Stratton, 1982. pp. 79-85.
40. Howell, D.S. (Group member). Mechanisms of Mineralization ( Normal) Group report. In: Biological Mineralization and Demineralization; Report of the Dahlem Workshop, Berlin, 1981. Nancollas, G. H., ed. Berlin, Springer-Verlag, 1982. pp. 350-63.
41. Moskowitz, R.W., Howell, D.S., Goldberg, V.C., Mankin, H.J., eds. Osteoarthritis: Diagnosis and Management. Philadelphia, Saunders, 1984. 585 pp.
42. Howell, D.S. Etiopathogenesis of osteoarthritis. Chapter 7. In: Osteoarthritis: Diagnosis and Management. Moskowitz, R.W., Howell, D.S., Goldberg, V.C., Mankin, H.J., eds. Philadelphia, Saunders, 1984. pp. 129-46.
43. Howell, D.S. Degenerative joint disease: etiologic factors and pathophysiology (Videorecording). Atlanta, Emory University School of Medicine, 1984. 53 min.
44. Manicourt, D.H., Howell, D.S., Moskowitz, R.W., Goldberg, V., Malemud, C. Studies of cartilage proteoglycans in an osteoarthritic rabbit model. In: Osteoarthritis, Current and Fundamental Problems. Peyron, J.G., ed. Paris, Ciba-Geigy, 1985. pp. 192-202.
45. Howell, D.S. Etiopathogenesis of osteoarthritis. Chapter 88. In: Arthritis and Allied Conditions. 10 th ed. McCarty, D.J., ed. Philadelphia, Lea and Febiger, 1985. pp. 1400-7.
46. Howell, D.S. Hypertrophic osteoarthropathy. Chapter 76. In: Arthritis and Allied Conditions. 10 th ed. McCarty, D.J., ed. Philadelphia, Lea and Febiger, 1985. pp. 1195-1201.
47. Howell, D.S. Osteoarthritis (degenerative joint disease). Chapter 457; The painful shoulder. Chapter 458; The painful back. Chapter 459. In: Cecil Textbook of Medicine. 17th ed. Wyngaarden, J.B., Smith, L.H., Jr., eds. Philadelphia, Saunders, 1985. pp. 1951-57.
48. Howell, D.S. Diseases due to the deposition of calcium pyrophosphate and hydroxyapatite. In: Textbook of Rheumatology. 2 nd ed. Kelley, W.N., Harris, E.D., Ruddy, S. and Sledge, C.B., eds. Philadelphia, Saunders, 1985. pp. 1398-1416.
49. Harris, E.D., Cohn, D.L., Goldstein, I.R., Howell, D.S., Lipsky, P.E., Phelps, P., Seibold, J.R. In: Rheumatology: Medical Knowledge Self-Assessment Program VII. Kay, C.F., ed. Philadelphia, American College of Physicians, 1985. p. 111.
50. Howell, D.S. Physiological and biochemical events in osteoarthritic cartilage (a brief review). In: Rheumatology – 85; Proceedings of the XVIth International Congress of Rheumatology, Sydney, 1985. Brooks, P.M., York, J.R., eds. Amsterdam, Excerpta Medica, 1985. pp. 161-5.
51. Pita, J.C., Manicourt, D.H., Muller, F.J., Howell, D.S. Study on the potential reversibility of OA in some experimental animal models. In: Articular Cartilage Biochemistry; International Workshop, Wiesbaden, Ger., 1985. Kuettner, K.E., Schleyerbach, R., Hascall, V.C., eds. New York, Raven Press, 1986. pp. 349-64.
52. Howell, D.S., Muniz, O.E., Carreno, M.R. The effect of glycosaminoglycan polysulfate ester (GAGPE) on proteoglycan degrading enzyme activity in an animal model of osteoarthritis (OA). In: Therapeutic Control of Inflammatory Diseases: New Approaches to Antirheumatic Drugs. Otterness, I., Lewis, A., Capetola, R., eds. New York, Raven Press, 1986. pp. 197-206.
53. Atkin, I., Howell, D.S., Pita, J.C., Castiglione, G., Agundez, A., Ornoy, A. A comparative ultrastructural study of the mineralization defect observed in low-phosphate vitamin D deficiency rickets and EHDP induced rickets in rats. In: Cell Mediated Calcification and Matrix Vesicles; Proceedings of the Ivth International Conference on Matrix Vesicles, Cambridge, 1985. Ali, S.Y., ed. New York, Elsevier Science, 1986. pp. 385-90.
54. Howell, D.S. Etiopathogenesis of osteoarthritis. In: L'Arthrose: Perspectives et Realites. Simon, L., Loyan, G., eds. Paris, Masson, 1987. pp. 1-11.
55. Howell, D.S., Dean, D.D., Malinin, T. A glimpse of chondroprotective therapy. In: L'Arthrose: Perspectives et Realites. Simon, L., Loyan, G., eds. Paris, Masson, 1987. p. 254.
56. Howell, D.S., Kapila, P., Malinin, T.I., Altman, R.D. Cartilage degradation and repair: a brief view of chondral protective treatment. In: New Perspectives in Rheumatological Treatment, Focus Tiaprofenic Acid. Huskisson, E.C., Shiokawa, Y., eds. Amsterdam, Excerpta Medica, 1987. pp. 3-13.
57. Altman, R.D., Gottlieb, N.L., Howell, D.S., eds. Chondroprotection. Semin. Arthritis Rheum. 17(2)Suppl 1:1-53, Nov. 1987.
58. Manicourt, D.H., Howell, D.S., Pita, J.C. Structure and function of the proteoglycan. In: Progress in Rheumatology. Kahn, M.F., et al, eds. Paris, Pfizer, 1987. pp. 19-24.
59. Howell, D.S. Osteoarthritis (degenerative joint disease); The painful shoulder; The painful back. In: Cecil Textbook of Medicine. 18 th ed. Wyngaarden, J.B., Smith, L.H., eds. Philadelphia, Saunders, 1988. pp. 2039-45.
60. Howell, D.S., and Manicourt, D.H. Complex polysaccharides. In: Primer on the Rheumatic Diseases. 9 th ed. Schumacher, H.R., ed. Atlanta, Arthritis Foundation, 1988. pp. 15-8.
61. Howell, D.S. Etiopathogenesis of osteoarthritis. Chapter 101. In: Arthritis and Allied Conditions. 11 th ed. McCarty, J.D., ed. Philadelphia, Lea & Febiger, 1989. pp. 1595-1604.
62. Howell, D.S., Dean, D.D., Pelletier, J.P. Therapeutic advances in cartilaginous injury: is the defect in synthesis or degradation? In: International Congress of Rheumatology, 17 th, Rio de Janiero, 1989. Proceedings of the ‘89 ILAR Congress. Sao Paulo, Companhia Melhoramentos de Sao Paulo, 1989. pp. 377-9.
63. Howell, D.S., Altman, R.D., Dean, D.D., Thonar, E.J.M. Early markers of osteoarthritis. In: International Congress of Rheumatology, 17 th, Rio de Janeiro, 1989. Proceedings of the ’89 ILAR Congress. Sao Paulo, Companhia Melhoramentos de Sao Paulo, 1989. pp. 326-8.
64. Mow, V.C., Setton, L.A., Ratcliffe, A., Howell, D.S., Buckwalter, J.A. Structure-function relationships of articular cartilage and the effects of joint instability and trauma on cartilage function. In: Cartilage Changes in Osteoarthritis. Brandt, K.D., ed. Indianapolis, Indiana University School of Medicine, 1990. pp. 22-42.
65. Howell, D.S., Muniz, O.E., Dean, D.D., Altman, R.D., Pelletier, J.P., Pelletier, J.M. Concepts of chondroprotective agents and use of animal models to test them. In: Cartilage Changes in Osteoarthritis. Brandt, K.D., ed. Indianapolis, Indiana University School of Medicine, 1990. pp. 142-4.
66. Jingushi, S., Joyce, M., Flanders, K., Hjelmeland, L., Roberts, A., Sporn, M., Muniz, O.E., Howell, D.S., Dean, D.D., Ryan, U.S., Bolander, M. Distribution of acidic fibroblast growth factor, basic fibroblast growth factor and transforming growth factor Beta-1 in the rat growth plate. In: Calcium Regulation and Bone Metabolism: Basic and Clinical Aspects; Proceedings of the 10 th International Conference on Calcium Regulating Hormones and Bone Metabolism, Montreal, 1989. Cohn, D.V., Glorieux, F.H., Martin, T.J., eds. Amsterdam, Excerpta Medica, 1990. pp. 298-303.
67. Howell, D.S., Altman, R.D., Dean, D.D., Muniz, O.E. The chondroprotective effect of Rumalon in an experimental model of OA. In: Osteoarthritis: Current Research and Prospects for Pharmacological Intervention. Russell, R.G.G., Dieppe , P.A., eds. London, IBC Technical Services, Ltd., 1991. pp. 154-62.
68. Altman, R.D., Dean, D., Muniz, O.E., Rodriguez, I., Carreno, M.R., Morales, S., Agundez, A., Madan, M.E., Annefeld, M., Howell, D.S. Prophylactic and therapeutic use of glycosaminoglycan-peptide complex in a rabbit model of osteoarthritis. In: Osteoarthritis: Is There Potential for Chondroprotective Therapy? Altman, R.D., Luescher, D., eds. Basel, EULAR Publishers, 1991. pp. 57-62.
69. Moskowitz, R.W., Howell, D.S., Goldberg, V.C., Mankin, H.J., eds. Osteoarthritis: Diagnosis and Management. 2 nd ed. Philadelphia, Saunders, 1992. 761 pp.
70. Howell, D.S., Treadwell BV, Trippell S.B. Etiopathogenesis of osteoarthritis. Chapter 9. In: Osteoarthritis: Diagnosis and Management. 2 nd ed. Moskowitz R.W., Howell, D.S., Goldberg, V.C., Mankin H.J., eds. Philadelphia, Saunders, 1992. pp. 233-52.
71. Howell, D.S., Dean, D.D. Biology, chemistry, and biochemistry of the mammalian growth plate. In: Disorders of Bone and Mineral Metabolism. Coe, F.L., Favus, M.J., eds. New York, Raven Press, 1992. pp. 313-53.
72. Howell, D.S. Osteoarthritis (Degenerative joint disease). Chapter 273; The painful shoulder. Chapter 274; The painful back. Chapter 275. In: Cecil's Textbook of Medicine. 19 th ed. Wyngaarden, J., Smith, L.H., eds. Philadelphia, Saunders, 1992. pp. 1557-60.
73. Peyron, J.G. (Panelists: Brandt, K.D., Howell, D.S., Kuettner, K.E., Vignon, E.) The impact of basic research on the diagnosis, understanding, and management of osteoarthritis. Part XIII. In: Articular Cartilage and Osteoarthritis; International Workshop, Wiesbaden, Ger., 1991. Kuettner, K.E., et al, eds. New York, Raven Press, 1992. pp. 669-81.
74. Howell, D.S., Pelletier, J.-P. Etiopathogenesis of osteoarthritis. In: Arthritis and Allied Conditions. 12 th ed. McCarty, D.J., Koopman, W.J., eds. Philadelphia, Lea & Febiger, 1993. pp. 1723-34.
75. Woessner, J.F., Jr., Howell, D.S., eds. Joint Cartilage Degradation: Basic and Clinical Aspects. New York, Dekker, 1993. 556 pp.
76. Howell, D.S., Altman, R.D., Pelletier, J.P., Martel-Pelletier, J., Dean, D.D. Disease modifying anti-rheumatic drugs: current status of their application in animal models of osteoarthritis. In: Osteoarthritic Disorders; Workshop, Monterey, CA, 1994. Kuettner, K.E., Goldberg, V.M., eds. Rosemont, IL, American Academy of Orthopaedic Surgeons, 1995. pp. 365-77.
77. Howell, D.S. The painful back. Chapter 405.4. In: Cecil Textbook of Medicine. 20th ed. Bennett, J.C., Plum, F., eds. Philadelphia, Saunders, 1996. pp. 2037-8.
78. Pelletier, J.-P., Martel-Pelletier, J., Howell, D.S. Etiopathogenesis of osteoarthritis. In: Arthritis and Allied Conditions. 13 th ed. Koopman, W.J., ed. Baltimore, Williams & Wilkins, 1997. pp. 1969-84.
79. Altman, R.D., Howell, D.S. Disease-modifying osteoarthritis drugs. In: Osteoarthritis. Brandt, K.D., Doherty, M., Lohmander, L.S., eds. Oxford, Oxford University Press, 1998. pp. 417-28.
80. Pelletier, J.-P., Martel-Pelletier, J., Howell, D.S. Etiopathogenesis of osteoarthritis. In: Arthritis and Allied Conditions. 14th ed. Koopman, W.J., ed. Baltimore, William & Wilkins, 2000. pp. 2195-2216.
81. Howell, D.S., Treadwell, B.V., Trippel, S.B. Etiopathogenesis of osteoarthritis. In: Osteoarthritis: Diagnosis and Medical/Surgical Management. 3rd ed. Moskowitz, R., Howell, D.S., Altman, R.D., Buckwalter, J., Goldberg, V., eds. Philadelphia, Saunders, 2001. pp. 233-52.
82. Moskowitz, R., Howell, D.S., Altman, R.D., Buckwalter, J., Goldberg, V., eds. Osteoarthritis: Diagnosis and Medical/Surgical Management. 3rd ed. Philadephia, Saunders, 2001. 761 pp.
83. Boyan, B.D., Schwartz, Z., Howell, D.S., Naski, M., Ranly, D.M., Sylvia, V.L., Dean, D.D. Biology, chemistry, and biochemistry of the mammalian growth plate. In: Disorders of Bone and Mineral Metabolism. 2 nd ed. Coe, F.L., Favus, M.J., eds. Philadelphia, Lippincott Williams and Wilkins, 2002. pp. 255-314.
84. Howell, D.S. The life of Klaus E. Kuettner. In: The Many Faces of Osteoarthritis. Hascall, V.C., Kuettner, K.E., eds. Basel, Birkhauser Verlag, 2002. pp. xxix-xxxviii.
Journal Articles:
1. Howell, D.S. Circulatory manifestations of obstruction of the superior vena cava in a patient with portal hypertension. Rhode Island Med. J. 33(12):659-62, Dec 1950.
2. Davis, J.O., Howell, D.S. Comparative effect of ACTH, cortisone and DCA on renal function, electrolyte excretion and water exchange in normal dogs. Endocrinology 52(3):245-55, Mar 1953.
3. Davis, J.O., Howell, D.S. Mechanisms of fluid and electrolyte retention in experimental preparations in dogs. II. With thoracic inferior vena cava constriction. Circ. Res. 1(2):171-8, Mar 1953.
4. Davis, J.O., Howell, D.S. Diuresis during maintenance of adrenalectomized dogs with ascites on cortisone. Endocrinology 53(6):653-60, Dec 1953.
5. Davis, J.O., Howell, D.S., Southworth, J.L. Mechanisms of fluid and electrolyte retention in experimental preparations in dogs. III. Effect of adrenalectomy and subsequent desoxycorticosterone acetate administration on ascites formation. Circ. Res. 1(3):260-70, May 1953.
6. Davis, J.O., Howell, D.S., Lacquer, G.L., Pierce E.C., 2 nd. Renal hemodynamic function, electrolyte metabolism and water exchange in adrenalectomized-hypophysectomized dogs. Am. J. Physiol. 176(3):411-8, Mar 1954.
7. Neefe, J.R., Norris, R.F., Rinehold, J.G., Mitchell, C.B., Howell, D.S. Carriers of hepatitis virus in the blood and viral hepatitis in whole blood recipients. I. Studies on donors suspected as carriers of hepatitis virus and as sources of post-transfusion viral hepatitis. J. Am. Med. Assoc. 154(13):1066-71, Mar 27 1954.
8. Howell, D.S., Davis, J.O. Relationship of sodium retention to potassium excretion by the kidney during administration of desoxycorticosterone acetate to dogs. Am. J. Physiol. 179(2):359-63, Nov 1954.
9. Davis, J.O., Howell, D.S., Hyatt, R.E. Effect of chronic pitressin administration on electrolyte excretion in normal dogs and in dogs with experimental ascites. Endocrinology 55(4):409-16, Oct 1954.
10. Davis, J.O., Howell, D.S., Hyatt, R.E. Sodium excretion in adrenalectomized dogs with chronic cardiac failure produced by pulmonary artery constriction. Am. J. Physiol. 183(2):263-8, Nov 1955.
11. Davis, J.O., Hyatt, R.E., Howell, D.S. Right-sided congestive heart failure in dogs produced by controlled progressive constriction of the pulmonary artery. Circ. Res. 3(3):252-8, May 1955.
12. Davis, J.O. Howell, D.S., Hyatt, R.E. Effects of acute and chronic digoxin administration in dogs with right-sided congestive heart failure produced by pulmonary artery constriction. Circ. Res. 3(3):259-63, May 1955.
13. Howell, D.S., Davis, J.O., Laquer, G.L. Effect of hypophysectomy on electrolyte excretion in dogs with ascites produced by thoracic inferior vena cava constriction. Circ. Res. 3(3):264-73, May 1955.
14. Howell, D.S. A study of the sensitized sheep cell agglutination reaction in rheumatoid arthritis; a preliminary report. Bull. Univ. of Miami School of Medicine, 10:8-11, 1956.
15. Howell, D.S., Ragan, C. The course of rheumatoid arthritis during four years of induced hyperadrenalism (IHA). Medicine 35(2):83-119, May 1956.
16. Davis, J.O., Howell, D.S., Goodkind, M.J., Hyatt, R.E. Accumulation of ascites during maintenance of adrenalectomized dogs with thoracic inferior vena cava constriction on a high sodium diet without hormone therapy. Am. J. Physiol. 185(1):230-4, Apr 1956.
17. Hamilton, W.F., Davis, J.O., Howell, D.S., Ellison, R.G., Hague, E.E., Brown, W.J. Experimental mitral stenosis and ascites formation. Am. J. Physiol. 190(3):500-2, Sep 1957.
18. Vaughn, P., Howell, D.S., Kiem, I. The comparative effects of phenylbutazone and G27202 (Metabolite I) in patients with rheumatoid arthritis: an assessment of methods for antirheumatic drug evaluation. Arthritis Rheum. 2(3):212-23, Jun 1959.
19. Howell, D.S., et al. Primer on the rheumatic diseases. Part I. Prepared by a committee of the American Rheumatism Association. J. Am. Med. Assoc. 171(9):1205-20, 1959.
20. Howell, D.S. Diagnosis of early rheumatoid arthritis. J. Fla. Med. Assoc. 47:680-1, Dec 1960.
21. Howell, D.S., Malcolm, J.J., Pike, R. The F-11 agglutinating factors in serums of patients with non-rheumatic diseases. Am. J. Med. 29:662-71, Oct 1960.
22. Slonim, R., Kiem, I., Vaughn, P., Howell, D.S. Evaluation of antirheumatic drug potency in a double blind study of patients with rheumatoid arthritis. Arthritis Rheum. 3(3):284, Jun 1960.
23. Howell, D.S., Delchamps, E., Reimer, W., Kiem, I. A profile of electrolytes in the cartilaginous plate of growing ribs. J. Clin. Invest. 39:919-29, Jun 1960.
24. Howell, D.S., Delchamps, E.E., Reimer, W. Spontaneous mineral deposition in sponge biopsy connective tissue. Proc. Soc. Exp. Biol. Med. 106:317-9, Feb 1961.
25. Howell, D.S., Vaughn, P.P., Broome, B.L. Serologic methods employing F-11 reactant as an aid to diagnosis of rheumatoid arthritis. Arthritis Rheum. 4:368-77, Aug 1961.
26. Slonin, R.R., Howell, D.S., Brown, H.E., Jr. Influence of griseofulvin upon acute gouty arthritis. Arthritis Rheum. 5:397-404, Aug 1962.
27. Savard, K., Marsh, J.M., Howell, D.S. Progesterone biosynthesis in luteal tissue: role of nicotinamide adenine dinucleotide phosphate and NADP-linked dehydrogenase. Endocrinology 73:554-63, Nov 1963.
28. Marchildon, A., Slonim R.R., Brown, H.E., Jr., Howell, D.S. Primary septic bursitis. J. Fla. Med. Assoc. 50:139-41, Aug 1963.
29. Howell, D.S. Concepts of calcifications. Arthritis Rheum. 6:736-42, Dec 1963.
30. Howell, D.S., Carlson, L. X-ray ultramicroanalysis of sulphur in calf costochondral plates. Acta. Chem. Scand. 1(Suppl. 17):79-83, 1963.
31. Howell, D.S., Franklin, E.D., Polley, H.F., Smiley, D. Rheumatoid factor (RF) and other immunological studies. Bull. Rheum. Dis. 14:3441-2, 1964.
32. Howell, D.S., Carlson, L. Sulfur metabolism in cartilage. A study of calcifying regions for microscopic distribution of sulfur and relationship of staining by Sudan Black. Exp. Cell Res. 34:568-80, May 1964.
33. Howell, D.S. Histologic observations and biochemical composition of rachitic cartilage with special reference to mucopolysaccharides. Arthritis Rheum. 8:337-54, Jun 1965.
34. Howell, D.S. Preliminary observations on local pH in gouty tophi and synovial fluid. Arthritis Rheum. 8(5):736-40, Oct 1965.
35. Salzman, R.T., Howell, D.S., Ricca, L.R. Aberrancy in clinical hallmarks of gouty arthritis: brief clinical report. Arthritis Rheum. 8(5):998-1001, Oct 1965.
36. Howell, D.S., Marquez, J.F., Pita, J.C. The nature of phospholipids in normal and rachitic costochondral plates. Arthritis Rheum. 8(6):1039-46, Dec 1965.
37. Howell, D.S., Carlson, L. The effect of papain on mineral deposition in the healing of rachitic epiphyses. Exp. Cell Res. 37:582-96, Mar 1965.
38. Howell, D.S., Pita, J.C., Marquez, J.F. Ultramicro-spectrophotometric determination of calcium in biologic fluids. Anal. Chem. 38(3):434-8, Mar 1966.
39. Howell, D.S., Carlson, L. Alterations in the composition of growth cartilage septa during calcification studied by microscopic x-ray elemental analysis. Exp. Cell Res. 51(1):185-95, Jul 1968.
40. Howell, D.S., Pita, J.C., Marquez, J.F., Madruga, J.E. Partition of calcium, phosphate and protein in the fluid phase aspirated at calcifying sites in epiphyseal cartilage. J. Clin. Invest. 47(5):1121-32, May 1968.
41. Dantini, D.J., Howell, D.S., Pita, J.C., Madruga J.E. Nucleating and inhibitor properties of fluid aspirated from calcifying sites by micropuncture. Calc. Tissue Res. 1968(Suppl):31.
42. Howell, D.S., Pita, J.C., Marquez, J.F., Gatter, R. Demonstration of macromolecular inhibitors of calcification and nucleational factors in fluid from calcifying sites in cartilage. J. Clin. Invest. 48(4):630-41, Apr 1969.
43. Howell, D.S., Vaughn, P.P., Slonim, R.R., Altman, R.D., Gamarra, M. The course of systemic lupus erythematosus in a subtropical medical center. J. Fla. Med. Assoc. 56(5):331-5, May 1969.
44. Slonim, R.R., Kiem, I.M., Howell, D.S., Brown, H.E., Jr. Evaluation of drug responses in the patient severely afflicted with rheumatoid arthritis. J. Fla. Med. Assoc. 56(5):336-41, May 1969.
45. Howell, D.S. A Floridian looks at arthritis. J. Fla. Med. Assoc. 56(5):345, May 1969.
46. Howell, D.S. The arthritis issue. J. Fla. Med. Assoc. 56(5):317, May 1969.
47. Pita, J.C., Cuervo, L.A., Madruga, J.E., Muller, F.J., Howell, D.S. Evidence for a role of proteinpolysaccharides in regulation of mineral phase separation in calcifying cartilage. J. Clin. Invest. 49(12):2188-97, Dec 1970.
48. Howell, D.S., Pita, J.C., Marquez, J.F., Madruga, J.E., Muller, F.J. Evidence for altered proteinpolysaccharide complexes (PPC) in fresh osteoarthritic cartilage in human hips. Calcif. Tissue Res. 1970(Suppl):127.
49. Cuervo, L.A., Pita, J.C., Howell, D.S. Ultra-microanalysis of pH, PCO2 and carbonic anhydrase activity at calcifying sites in cartilage. Calcif. Tiss. Res. 7(3):220-31, 1971.
50. Howell, D.S. Review Article. Current concepts of calcification. J. Bone Joint Surg. Am. 53A(2):250-7, Mar 1971.
51. Howell, D.S., Altman, R.D., Brown, H.E., Jr., Gottlieb, N.L. A comprehensive regimen for osteoarthritis. Med. Clin. North Am. 55(2):457-69, Mar 1971.
52. Sapolsky, A.I., Altman, R.D., Woessner, J.F., Jr., Howell, D.S. The action of cathepsin D in human articular cartilage on proteoglycans. J. Clin. Invest. 52(3):624-33, Mar 1973.
53. Altman, R.D., Pita, J.C., Howell, D.S. Degradation of proteoglycans in human osteoarthritic cartilage. Arthritis Rheum. 16(2):179-85, Mar-Apr 1973.
54. Altman, R.D., Muniz, O.E., Pita, J.C., Howell, D.S. Articular chondrocalciniosis: microanalysis of pyrophosphate (PPi) in synovial fluid and plasma. Arthritis Rheum. 16(2):171-78, Mar-Apr 1973.
55. Cuervo, L.A., Pita, J.C., Howell, D.S. Inhibition of calcium phosphate mineral growth by proteoglycan aggregate fractions in a synthetic lymph. Calcif. Tiss. Res. 13(1):1-10, 1973.
56. Simon, D.R., Berman, I., Howell, D.S. Relationship of extracellular matrix vesicles to calcification in normal and healing rachitic epiphyseal cartilage. Anat. Rec. 176(2):167-79, Jun 1973.
57. Howell, D.S., Bollet, A.J. Introduction. Workshop on osteoarthritis. Fed. Proc. 32(4):1457-8, Apr 1973.
58. Sapolsky, A.I., Altman, R.D., Howell, D.S. Cathepsin D activity in normal and osteoarthritic human cartilage. Fed. Proc. 32(4):1489-93, Apr 1973.
59. Sapolsky, A.I., Howell, D.S., Woessner, J.F., Jr. Neutral proteases and cathepsin D in human articular cartilage. J. Clin. Invest. 53(4):1044-53, Apr 1974.
60. Pita, J.C., Howell, D.S. Some analytical ultramicro-techniques. J. Dent. Res. 53(2):280-7, Mar-Apr 1974.
61. Kuettner, K.E., Sorgente, N., Croxen, R.L., Howell, D.S., Pita, J.C. Lysozyme in preosseous cartilage. VII. Evidence for physiological role of lysozyme in normal endochondral calcification. Biochem. Biophys. Acta 372:335-44, 1974.
62. Howell, D.S., Pita, J.C., Sorgente, N., Kuettner, K. Possible role of lysozyme in degradation of osteoarthritic cartilage. Trans. Assoc. Am. Physicians 87:169-79, 1974.
63. Howell, D.S. Pemberton Lecture. Degradative enzymes in osteoarthritic human articular cartilage. Arthritis Rheum. 18(2):167-77, Mar-Apr 1975.
64. Howell, D.S., Muniz, O., Pita, J.C., Enis, J.E. Extrusion of pyrophosphate into extracellular media by osteoarthritic cartilage incubates. J. Clin. Invest. 56(6):1473-80, Dec 1975.
65. Sapolsky, A.I., Woessner, J.F., Jr., Howell, D.S. A photometric assay for protease digestion of the proteoglycan subunit. Anal. Biochem. 67(2):649-54, Aug 1975.
66. Kuettner, K.E., Pita, J.C., Howell, D.S., Sorgente, N., Eisenstein, R. The possible function of lysozyme in cartilage metabolism. Ann. Rheum. Dis. 34:69-70, 1975.
67. Howell, D.S., Pita, J.C., Alvarez, J. Possible role of extracellular matrix vesicles in initial calcification of healing rachitic cartilage. Fed. Proc. 35(2):122-6, Feb 1976.
68. Howell, D.S. Calcification mechanisms. Isr. J. Med. Sci. 12(2):91-7, Feb 1976.
69. Sapolsky, A.I., Howell, D.S. Proteolytic enzyme in human cartilage: the pathogenesis of osteoarthritis. Compr. Ther. 2(10):33-40, Oct 1976.
70. Howell, D.S., Muniz, O., Pita, J.C., Arsenis, C. Preliminary observations on phosphatases in articular cartilages. Arthritis Rheum. 19(Suppl 3):495-8, May-Jun 1976.
71. Howell, D.S., Muniz, O., Pita, J.C., Enis, J.E. Pyrophosphate release by osteoarthritis cartilage incubates. Arthritis Rheum. 19(Suppl 3):488-94, May-Jun 1976.
72. Howell, D.S., Sapolsky, A.I., Pita, J.C., Woessner, J.F. The pathogenesis of osteoarthritis. Semin. Arthritis Rheum. 4(4):365-83, May 1976.
73. Howell, D.S., Pita, J.C. Calcification of growth plate cartilage with special reference to studies on micropuncture fluids. Clin. Orthop. (118):208-29, Jul-Aug 1976.
74. Sapolsky, A.I., Keiser, H.D., Howell, D.S., Woessner, J.F., Jr. Metalloproteases of human articular cartilage that digest cartilage proteoglycan at neutral and acid pH. J. Clin. Invest. 58(4):1030-41, Oct 1976.
75. Howell, D.S., Muniz, O., Pita, J.C., Enis, J.E. Extrusion of pyrophosphate into extracellular media by osteoarthritic cartilage intubates. Calcif. Tissue Res. 21(Suppl):349-53, Aug 1976.
76. Howell, D.S., Moskowitz, R.W. Introduction: Symposium on Osteoarthritis. A brief review of research and directions of future investigation. Arthritis Rheum. 20(Suppl):S96-SlO3, Jul-Aug 1977.
77. Woessner, J.F., Jr., Sapolsky, A.I., Howell, D.S. Role of proteolytic enzymes in cartilage matrix breakdown in osteoarthritis. Arthritis Rheum. 20(Suppl):Sll6, Jul-Aug 1977.
78. Morales, T.I., Woessner, J.F., Jr., Howell, D.S., Marsh, J.M., LeMaire, W.J. A microassay for the direct demonstration of collagenolytic activity in Graafian follicles of the rat. Biochem. Biophys. Acta 524(2):428-34, Jun 9 1978.
79. Dereszewski, G., Howell, D.S. The role of matrix vesicle in calcification. Trends Biochem. Sci. 3(7):151-3, Jul 1978.
80. Pita, J.C., Blanco, L.N., Howell, D.S. Determination of total and unbound calcium in nanoliter samples of cartilage fluid and serum. Anal. Biochem. 90(1):126-35, Oct 1978.
81. Howell, D.S., Blanco, L.N., Pita, J.C., Muniz, O. Further characterization of a nucleational agent in hypertrophic cell extracellular cartilage fluid. Metab. Bone Dis. Rel. Res. 1(2):155-60, 1978.
82. Ryan, J.W., Ryan, U.S., Habliston, D., Martin, L., Howell, D.S. Synthesis of prostglandins by pulmonary endothelial cells. Trans. Assoc. Am. Physicians 91:343-50, 1978. (Introductory Statements)
83. Moskowitz, R.W., Howell, D.S., Goldberg, V.M., Muniz, O.E., Pita, J.C. Cartilage proteoglycan alterations in an experimentally induced model of rabbit osteoarthritis. Arthritis Rheum. 22(2):155-63, Feb 1979.
84. Howell, D.S., Woessner, J.F., Jr., Jiminez, S., Seda, H., Schumacher, H.R. A view on the pathogenesis of osteoarthritis. Bull. Rheum. Dis. 29(8):996-1001, 1978-79.
85. Malemud, C.J., Weitzman, G.A., Norby, D.P., Sapolsky, A.I., Howell, D.S. Metal-dependent neutral proteoglycanase activity from monolayer-cultured lapine articular chondrocytes. J. Lab. Clin. Med. 93(6):1018-30, Jun 1979.
86. Howell, D.S., Muniz, O.E., Blanco, L.N., Pita, J.C. A micropuncture study of growth cartilage in phosphonate (EHDP) induced rickets. Calcif. Tiss. Int. 30(1):35-42, 1980.
87. Tenenbaum, J., Muniz, O., Schumacher, H.R., Good, A.E., Howell, D.S. Comparison of phosphohydrolase activities from articular cartilage in calcium pyrophosphate deposition disease and in primary osteoarthritis. Arthritis Rheum. 24(3):492-500, Mar 1981.
88. Malemud, C.J., Norby, D.P., Sapolsky, A.I., Matsuta, K., Howell, D.S., Moskowitz, R.W. Neutral proteinases from articular chondrocytes in culture. 1. A latent collagenase that degrades human cartilage type II collagen. Biochim. Biophys. Acta 657(2):517-29, Feb 13 1981.
89. Sapolsky, A.I., Malemud, C.J., Norby, D.P., Moskowitz, R.W., Matsuta, K., Howell, D.S. Neutral proteinases from articular chondrocytes in culture. 2. Metal-dependent latent neutral proteoglycanase, and inhibitory activity. Biochim. Biophys. Acta 658(1):138-47, Mar 13 1981.
90. Pita, J.C., Muller, F.J., Howell, D.S. Characterization of rabbit articular cartilage by rate-zonal centrifugation. Semin. Arthritis Rheum. 1l(Suppl. 1):23-4, 1981.
91. Altman, R.D., Tenenbaum, J., Pardo, V., Blanco, L.N., Howell, D.S. Morphological changes and swelling properties of osteoarthritic dog cartilage. Semin. Arthritis Rheum. 11(Suppl. 1):39-40, 1981.
92. Woessner, J.F., Pelletier, J.-P., Martel-Pelletier, J., Enis, J., Howell, D.S. Direct measurement of cartilage collagenolytic activity in human osteoarthritis. Semin. Arthritis Rheum. ll(Suppl. 1):58-9, 1981.
93. Malemud, C.J., Norby, D.P., Moskowitz, R.W., Goldberg, V.M., Sapolsky, A.I., Howell, D.S. Neutral proteinases from articular chondrocytes in culture that degrade synthetic substrates and cartilage macromolecules. Semin. Arthritis Rheum. ll(Suppl. 1):61-3, 1981.
94. Sapolsky, A.I., Malemud, C.J., Norby, D.P., Matsuta, K., Howell, D.S. Neutral metalloproteases and their inhibitors from cultured articular chondrocytes. Semin. Arthritis Rheum. ll(Suppl. 1):71-2, 1981.
95. Gay, C.V., Anderson, R.E., Schraer, H., Howell, D.S. Identification of carbonic anhydrase in chick growth plate cartilage. J. Histochem. Cytochem. 30(4):391-4, Apr 1982.
96. Sapolsky, A.I., Howell, D.S. Further characterization of a neutral metalloprotease isolated from human articular cartilage. Arthritis Rheum. 25(8):981-8, Aug 1982.
98. Morales, T.I., Kuettner, K.E., Howell, D.S., Woessner, J.F. Characterization of the metalloproteinase inhibitor produced by bovine articular chondrocyte cultures. Biochim. Biophys. Acta. 760(2):221-9, Oct 18 1983.
99. Pelletier, J.P., Martel-Pelletier, J., Howell, D.S., Ghandur-Mnaymneh, L., Enis, J.E., Woessner, J.F., Jr. Collagenase and collagenolytic activity in human osteoarthritic cartilage. Arthritis Rheum. 26(1):63-8. Jan 1983.
100. Pelletier, J.P., Martel-Pelletier, J., Altman, R.D., Ghandur-Mnaymneh, L., Howell, D.S., Woessner, J.F., Jr. Collagenolytic activity and collagen matrix breakdown of the articular cartilage in the pond-nuki dog model of osteoarthritis. Arthritis Rheum. 26(7):866-74, Jul 1983.
101. Sapolsky, A.I., Sheff, M.F., Matsuta, K., Howell, D.S., Moskowitz, R.W., Goldberg, V., Norby, D.P., Malemud, C.J. ‘Gelatinase-Like’ activity from articular chondrocytes in monolayer culture. Biochim. Biophys. Acta. 76(2):227-31, Apr 5 1983.
102. Altman, R.D., Meenan, R.F., Hochberg, M.C., Giles, G.B., Jr., Brandt, K., Cooke, T.D.V., Greenwald, R.A., Howell, D.S., Kaplan, D., Koopman, W.J., Mankin, H., Mikkelsen, W.M., Moskowitz, R., Sokoloff, L. An approach to developing criteria for the clinical diagnosis and classification of osteoarthritis: a status report of the American Rheumatism Association Diagnostic Subcommittee on Osteoarthritis. J. Rheumatol. 10(2):180-3, Apr 1983.
103. Howell, D.S., Pita, J.C., Woessner, J.F., Jr. Discussion: Which comes first: crystals, necrosis, or inflammation? J. Rheumatol. 10(Suppl. 9):59-61, 1983.
104. Altman, R.D., Tenenbaum, J., Latta, L., Riskin, W., Blanco, L.N., Howell, D.S. Biomechanical and biochemical properties of dog cartilage in experimentally induced osteoarthritis. Ann. Rheum. Dis. 43(1):83-90, Feb. 1984.
105. Howell, D.S., Martel-Pelletier, J., Pelletier, J.P., Morales, S.M., Muniz, O.E. NTP Pyrophosphohydrolase in human chondrocalcinotic and osteoarthritic cartilage. II. Further studies on histologic and subcellular distribution. Arthritis Rheum. 27(2):193-6, Feb. 1984.
106. Muniz, O., Pelletier, J.P., Martel-Pelletier, J., Morales, S., Howell, D.S. NTP Pyrophosphohydrolase in human chondrocalcinotic and osteoarthritic cartilage. I. Some biochemnical properties. Arthritis Rheum. 27(2):186-92, Feb. 1984.
107. Martel-Pelletier, J., Pelletier, J.P., Cloutier, J.M., Howell, D.S., Ghandur-Mnaymneh, L., Woessner, J.F. Neutral proteases capable of proteoglycan digesting activity in osteoarthritis and normal human articular cartilage. Arthritis Rheum. 27(3):305-12, Mar 1984.
108. Manicourt, D., Howell, D.S., Moskowitz, R.W., Goldberg, V., Malemud, C., Pita, J.C. Application of new techniques to separation of proteoglycan aggregates from normal and destabilized rabbit articular cartilages. Acta Biol. Hung. 35(2-4):137-42, 1984.
109. Martel-Pelletier, J., Cloutier, J.M., Howell, D.S., Pelletier, J.P. Human rheumatoid arthritic cartilage and its neutral proteoglycan-degrading proteases: the effects of antirheumatic drugs. Arthritis Rheum. 28(4):405-12, Apr 1985.
110. Dean, D.D., Muniz, O.E., Berman, I., Pita, J.C., Carreno, M.R., Woessner, J.F., Jr., Howell, D.S. Localization of collagenase in the growth plate of rachitic rats. J. Clin. Invest. 76(2):716-22, Aug 1985.
111. Pelletier, J.P., Martel-Pelletier, J., Ghandur-Mnaymneh, L., Howell, D.S., Woessner, J.F., Jr. Role of synovial membrane inflammation in cartilage matrix breakdown in the pond-nuki dog model of osteoarthritis. Arthritis Rheum. 28(5):554-61, May 1985.
112. Dean, D.D., Sellers, A., Howell, D.S., Kerwar, S.S., Woessner, J.F., Jr. Ascorbic acid stimulates the resorption of canine articular cartilage induced by a factor derived from activated rabbit macrophages. Rheumatol. Int. 5(3):103-7, 1985.
113. Howell, D.S., Tozman, E.C.S. Present concepts of osteoarthritis. Seapal Bulletin (Australian Rheum. Journal) 3:2-15, 1985.
114. Atkin, I., Pita, J.C., Ornoy, A., Agundez, A., Castiglione, G., Howell, D.S. Effects of vitamin D metabolites on healing of low phosphate, vitamin D-deficient induced rickets in rats. Bone 6(2):113-23, 1985.
115. Manicourt, D.H., Pita, J.C., Pezon, C.F., Howell, D.S. Characterization of the proteoglycans recovered under nondissociative conditions from normal articular cartilage of rabbits and dogs. J. Biol. Chem. 261(12):5426-33, Apr 25 1986.
116. Carreno, M.R., Muniz, O.E., Howell, D.S. The effect of glycosaminoglycan polysulfuric acid ester on articular cartilage in experimental osteoarthritis: effects on morphological parameters of disease severity. J. Rheumatol. 13(3):490-7, Jun 1986.
117. Akizuki, S., Mow, V.C., Muller, F., Pita, J.C., Howell, D.S., Manicourt, D.H. Tensile properties of human knee joint cartilage. I. Influence of ionic conditions, weight bearing, and fibrillation on the tensile modulus. J. Orthop. Res. 4(4):379-92, 1986.
118. Howell, D.S., Carreno, M.R., Pelletier, J.-P., Muniz, O.E. Articular cartilage breakdown in a lapine model of osteoarthritis: action of glycosaminoglycan polysulfate ester (GAGPS) on proteoglycan degrading enzyme activity, hexuronate and cell counts. Clin. Orthop. 213:69-76, Dec 1986.
119. Howell, D.S. Pathogenesis of osteoarthritis. Am. J. Med. 80(4B):24-8, Apr 28 1986.
120. Altman, R.D., Howell, D.S., Gottlieb, N.L. New directions in therapy of osteoarthritis. Semin. Arthritis Rheum. 17(Suppl 1):1-2, Nov 1987.
121. Altman, R.D., Bloch, D.A., Bole, G.G., Jr., Brandt, K.D., Cooke, D.V., Greenwald, R.A., Hochberg, M.C., Howell, D.S., Kaplan, D., Koopman, W.J., et al. Development of clinical criteria for osteoarthritis. J. Rheumatol. 14 Spec No:3-6, May 1987.
122. Altman, R.D., Howell, D.S., Muniz, O.E., Dean, D.D. The effect of glycosaminoglycan polysulfuric acid ester on articular cartilage in experimental arthritis: effects on collagenolytic enzyme activity and cartilage swelling properties. J. Rheumatol. 14 Spec No:127-9, May 1987.
123. Akizuki, S., Mow, V.C., Muller, F., Pita, J.C., Howell, D.S. Tensile properties of human knee joint cartilage. II. Correlations between weight bearing and tissue pathology and the kinetics of swelling. J. Orthop. Res. 5(2):173-86, 1987.
124. Atkin, I., Ornoy, A., Pita, J.C., Muniz, O.E., Agundez, A., Castiglione, G., Howell, D.S. EHDP-induced rachitic syndrome in rats is not reversed by vitamin D metabolites. Anat. Rec. 220(1):22-30, Jan 1988.
125. Larsson, P.A., Howell, D.S., Pita, J.C., Blanco, L.N. Aspiration and characterization of predentin fluid in developing rat teeth by means of a micropuncture and micro-analytical technique. J. Dent. Res. 67(5):870-75, May 1988.
126. Manicourt, D.H., Pita, J.C., McDevitt, C.A., Howell, D.S. Superficial and deeper layers of dog normal articular cartilage: role of hyaluronate and link protein in determining the sedimentation coefficients distribution of the nondissociatively extracted proteoglycans. J. Biol. Chem. 263(26):13121-9, Sep 15 1988.
127. Altman, R.D., Kapila, P., Dean, D.D., Howell, D.S. Future therapeutic trends in osteoarthritis. Scand. J. Rheumatol. Suppl. 77:37-42, 1988.
128. Altman, R.D., Dean, D.D., Muniz, O.E., Howell, D.S. Prophylactic treatment of a canine osteoarthritis with glycosaminoglycan polysulfuric acid ester. Arthritis Rheum. 32(6):759-66, Jun 1989.
129. Howell, D.S. The research arena of this symposium and an outlook for future treatment of osteoarthritis. J. Rheumatol. Suppl. 18:1-4, Aug 1989.
130. Blair, H.C., Dean, D.D., Howell, D.S., Teitelbaum, S.L., Jeffrey, J.J. Hypertrophic chondrocytes produce immunoreactive collagenase in vivo. Connec. Tiss. Res. 23(1):65-73, 1989.
131. Altman, R.D., Dean, D.D., Muniz, O.E., Howell, D.S. Therapeutic treatment of canine osteoarthritis with glycosaminoglycan polysulfuric acid ester. Arthritis Rheum. 32(10):1300-7, Oct 1989.
132. Dean, D.D., Muniz, O.E., Howell, D.S. Association of collagenase and tissue inhibitor of metalloproteinases (TIMP) with hypertrophic cell enlargement in the growth plate. Matrix 9(5):366-75, Nov 1989.
133. Dean, D.D., Martel-Pelletier, J., Pelletier, J.-P., Howell, D.S., Woessner, J.F. Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage. J. Clin. Invest. 84(2):678-85, Aug 1989.
134. Manicourt, D.H., Thonar, E.J., Pita, J.C., Howell, D.S. Changes in the sedimentation profile of proteoglycan aggregates in early experimental canine osteoarthritis. Conn. Tiss. Res. 23(1):33-50, 1989.
135. Dean, D.D., Muniz, O.E., Woessner, J.F., Howell, D.S. Production of collagenase and tissue inhibitor of metalloproteinases (TIMP) by rat growth plates in culture. Matrix 10(5):320-30, Oct 1990.
136. Axelsson, I., Pita, J.C., Howell, D.S., Lorentzon, R., Berman, I., Boquist, L. Kinetics of proteoglycans and cells in growth plates of normal diabetic and malnourished rats. Pediatr. Res. 27(1):41-4, Jan 1990.
137. Dean, D.D., Muniz O.E., Rodriquez, I., Carreno, M.R., Morales, S., Agundez, A., Madan, M.E., Altman, R.D., Annefeld, M., Howell, D.S. Amelioration of lapine glycosaminoglycan-peptide association complex (Rumalon). Arthritis Rheum. 34(3):304-13, Mar 1991.
138. Masse, P.G., Colombo, V.E., Gerber, F., Howell, D.S., Weiser, H. Morphological abnormalities in vitamin B6 deficient tarsometatarsal chick cartilage. Scanning Microsc. 4(3):667-73; discussion 674, 1990.
139. Altman, R.D., Block, D.A., Brandt, K.D., Cooke, D.V., Greenwald, R.A., Hochberg, M.C., Howell, D.S., Ike, R.W., Kaplan, D., Koopman, W., et al. Osteoarthritis: definitions and criteria. Ann. Rheum. Dis. 49(3):201, Mar 1990.
140. Howell, D.S. Biochemical aspects of osteoarthritis. Scand. J. Rheumatol. Suppl. 81:5-7, 1990.
141. Howell, D.S., Pita, J.C., Muller, F.J., Manicourt, D.H., Altman, R.D. Treatment of osteoarthritis with tiaprofenic acid: biochemical and histological protection against cartilage breakdown in the pond-nuki canine model. J. Rheumatol. Suppl. 1991:138-42.
142. Manicourt, D.H., Pita, J.C., Thonar, E.J.M., Howell, D.S. Proteoglycans nondissociatively extracted from different zones of canine normal articular cartilage: variations in the sedimentation profile of aggregates with degree of physiological stress. Conn. Tiss. Res. 26(4):231-46, 1991.
143. Altman, R.D., Alarcon, G., Appelrouth, D., Bloch D., Borenstein, D., Brandt, K., Brown, C., Cooke, T.D., Daniel, W., Feldman, D., Greenwald, R., Hochberg, M., Howell, D.S., Ike, R., Kapila, P., Kaplan, D., Koopman, W., Marino, C., McDonald, E., McShane, D.J., Medsger, T., Michel, B., Murphy, W.A., Osial, T., Ramsey-Goldman, R., Rothschild, B., Wolfe, F. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum. 34(5):505-14, May 1991.
144. Howell, D.S., Pita, J.C., Muller, F.J., Manicourt, D.H., Altman, R.D. Treatment of osteoarthritis with tiaprofenic acid and indomethacin: use of the pond-nuki canine model for biochemical and histological studies. Drug Invest. 3 (Suppl 2):66-70, 1991.
145. Dean, D.D., Muniz, O.E., Rodriguez, I., Carreno, M.R., Morales, S.M., Agundez, A., Madan, M.E., Altman, R.D., Annefeld, M., Howell, D.S. Rumalon treatment of lapine osteoarthritis. International Monitor 2:77-8, 1991.
146. Atkin, I., Dean, D.D., Muniz, O.E., Agundez, A., Castiglione, G., Cohen, G., Howell, D.S., Ornoy, A. Enhancement of osteoinduction by vitamin D metabolites in rachitic host rats. J. Bone Min. Res. 7(8):863-75, Aug 1992.
147. Dean, D.D., Schwartz, Z., Muniz, O.E., Gomez, R., Swain, L.D., Howell, D.S., Boyan, B.D. Matrix vesicles are enriched in metalloproteinases that degrade proteoglycans. Calcif. Tiss. Int. 50(4):342-349, Apr 1992.
148. Dean, D.D., Schwartz, Z.V., Muniz, O.E., Gomez, R., Swain, L.D., Howell, D.S., Boyan, B.D. Matrix vesicles contain metalloproteinases that degrade proteoglycans. Bone Miner. 17(2):172-6, May 1992.
149. Howell, D.S., Muller, F., Manicourt, D.H. A mini review: Proteoglycan aggregate profiles in the pond-nuki dog model of osteoarthritis and in canine disuse atrophy. Br. J. Rheumatol. 31 Suppl 1:7-11, 1992.
150. Rogachefsky, R.A., Dean, D.D., Howell, D.S., Altman, R.D. Treatment of canine osteoarthritis with insulin-like growth factor-1 (IGF-1) and sodium pentosan polysulfate. Osteoarthritis Cartilage 1(2):105-14, Apr 1993.
151. Howell, D.S., Altman, R.D. Cartilage repair and conservation in osteoarthritis: a brief review of some experimental approaches to chondroprotection. Rheum. Dis. Clin. North Am. 19(3):713-24, Aug 1993.
152. Setton, L.A., Mow, V.C., Muller, F.J., Pita, J.C., Howell, D.S. Altered structure-function relationships for articular cartilage in human osteoarthritis and an experimental canine model. Agents Actions Suppl. 39:27-48, 1993.
153. Rogachefsky, R.A., Dean, D.D., Howell, D.S., Altman, R.D. Treatment of canine osteoarthritis with sodium pentosan polysulfate and insulin-like growth factor-1. Ann. N. Y. Acad. Sci. 732:392-4, Dec 6, 1994.
154. Dean, D.D., Schwartz, Z., Bonewald, L., Muniz, O.E., Morales, S., Gomez, R., Brooks, B.P., Qiao, M., Howell, D.S., Boyan, B.D. Matrix vesicles produced by osteoblast-like cells in culture become significantly enriched in proteoglycan-degrading metalloproteinases after addition of beta-glycerophosphatate and ascorbic acid. Calcif. Tiss. Int. 54(5):399-408, May 1994.
155. Howell, D.S., Altman, R.D. Chondroprotection in treatment of osteoarthritis: does it exist? Rev. Bras. Reumatol. 34:1-3, 1994.
156. Muller, F.J., Setton, L.A., Manicourt, D.H., Mow, V.C., Howell, D.S., Pita, J.C. Centrifugal and biochemical comparison of proteoglycan aggregates from articular cartilage in experimental joint disuse and joint instability. J. Orthop. Res. 12(4):498-508, Jul 1994.
157. Setton, L.A., Mow, V.C., Muller, F.J., Pita, J.C, Howell, D.S. Mechanical properties of canine articular cartilage are significantly altered following transection of the anterior cruciate ligament. J. Orthop. Res. 12(4):451-63, Jul 1994.
158. Masse, P.G., Yamauchi, M., Mahuren, J.D., Coburn, S.P., Muniz, O.E., Howell, D.S. Connective tissue integrity is lost in vitamin B-6 deficient chicks. J. Nutr. 125(1):26-34, Jan 1995.
159. Grumbles, R.M., Howell, D.S., Howard G.A., Roos, B.A., Setton, L.A., Mow, V.C., Ratcliffe, A., Muller, F.J., Altman, R.D. Cartilage metalloproteases in disuse atrophy. J. Rheumatol. Suppl. 43:146-8, Feb 1995.
160. Setton, L.A., Mow, V.C., Howell, D.S. The mechanical behavior of articular cartilage in shear is altered by transection of the anterior cruciate ligament. J. Orthop. Res. 13(4):473-82, Jul 1995.
161. Re, P., Valhmu, W.B., Vostrejs, M., Howell, D.S., Fischer, S.G., Ratcliffe, A. Quantitative polymerase chain reaction assay for aggrecan and link protein gene expression in cartilage. Anal. Biochem. 225(2):356-60, Mar 1 1995.
162. Grumbles, R.M., Howell, D.S., Wenger, L., Altman, R.D., Howard, G.A., Roos, B.A. Hepatocyte growth factor and its actions in growth plate chondrocytes. Bone 19(3):255-61, Sep 1996.
163. Grumbles, R.M., Shao, L., Jeffrey, J.J., Howell, D.S. Regulation of rat interstitial collagenase gene expression in growth cartilage and chondrocytes by vitamin D3, interleukin-lBeta, and okadaic acid [sic]. J. Cell. Biochem. 62(4):395-409, Dec 1996.
164. Dean, D.D., Boyan, B.D., Muniz, O.E., Howell, D.S., Schwartz, Z. Vitamin D metabolites regulate matrix vesicle metalloproteinase content in a cell maturation-dependent manner. Calcif. Tiss. Int. 59(2):109-16, Aug 1996.
165. Masse, P.G., Rimnac C.M., Yamauchi, M., Coburn, S.P., Rucker, R.B., Howell, D.S., Boskey, A.L. Pyridoxine deficiency affects biomechanical properties of chick tibial bone. Bone 18(6):567-74, Jun 1996.
166. Dean, D.D., Schwartz, Z., Schmitz, J., Muniz, O.E., Lu, Y., Calderon, F., Howell, D.S., Boyan, B.D. Vitamin D regulation of metalloproteinase activity in matrix vesicles. Connect. Tissue Res. 35(1-4):331-6, 1996.
167. Setton, L.A., Mow, V.C., Muller, F.J., Pita, J.C., Howell, D.S. Mechanical behavior and biochemical composition of canine knee cartilage following periods of joint disuse and disuse with remobilization. Osteoarthritis Cartilage 5(1):1-16, Jan 1997.
168. Grumbles, R.M., Shao, L., Jeffrey, J.J., Howell, D.S. Regulation of the rat interstitial collagenase promoter by IL-1 beta, c-Jun and ras-dependent signaling in growth plate chondrocytes [sic]. J. Cell Biochem. 67(1):92-102, Oct 1997.
169. Masse, P.G., Carrino, D.A., Morris, N., Wenger, L., Mahuren, J.D., Howell, D.S. Loss of decorin from the surface zone of articular cartilage in a chick model of osteoarthritis. Acta Histochem. 99(4):431-44, Nov 1997.
170. Dean, D.D., Schwartz, Z., Muniz, O.E., Arsenis, C.H., Boyan, B.D., Howell, D.S. Interleukin-1 alpha and beta in growth plate cartilage are regulated by vitamin D metabolites in vivo. J. Bone Min. Res. 12(10):1560-9, Oct 1997.
171. Masse, P.G., Ziv, I., Cole, D.E., Mahuren, J.D., Donovan, S.M., Yamauchi, M., Howell, D.S. A cartilage matrix deficiency experimentally induced by vitamin B6 deficiency. Proc. Soc. Exp. Biol. Med. 217(1):97-103, Jan 1998.
172. Sun, Y., Cheung, J.M., Martel-Pelletier, J., Pelletier, J.P., Wenger, L., Altman, R.D., Howell, D.S., Cheung, H.S. Wild type and mutant P53 differentially regulate the gene expression of human collagenase-3 (HMMP-13). J. Biol. Chem. 275(15):111327-32, Apr 14 2000.
173. Masse, P.G., Delvin, E.E., Hauschka, P.V., Donovan, S.M., Grynpas, M.D., Mahuren, B.A., Watkins, B.A., Howell, D.S. Pertubations in factors that modulate osteoblast functions in vitamin B6 deficiency. Can. J. Physiol. Pharmacol. 78(11):904-11, Nov 2000.
174. Dean, D.D., Boyan, B.D., Schwartz, Z., Muniz, O.E., Carreno, M.R., Maeda, S., Howell, D.S. Effect of 1 alpha,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3 on metalloproteinase activity and cell maturation in growth plate cartilage in vivo. Endocrine 14(3):311-23, Apr 2001.
175. Leroux, M.A., Cheung, H.S., Bau, J.L., Wang, J.Y., Howell, D.S., Setton, L.A. Altered mechanics and histomorphometry of canine tibial cartilage following joint immobilization. Osteoarthritis Cartilage 9(7):633-40, Oct 2001.
176. Bai, G., Howell, D.S., Howard, G.A., Roos, B.A., Cheung, H.S. Basic calcium phosphate crystals up-regulate metalloproteinases but down-regulate tissue inhibitor of metalloproteinase in human fibroblasts. Osteoarthritis Cartilage 9(5):416-22, Jul 2001.
177. Clemmons, D.R., Busby, W.H., Jr., Garmong, A., Schultz, D.R., Howell, D.S., Altman, R.D., Karr, R. Inhibition of insulin-like growth factor binding protein 5 proteolysis in articular cartilage and joint fluid results in enhanced concentrations of insulin-like growth factor 1 and is associated with improved osteoarthritis. Arthritis Rheum. 46(3):694-703, Mar 2002.
178. Howell, D.S. Articular cartilage calcification and matrix vesicles. Curr. Rheumatol. Rep. 4(3):265-9, Jun 2002.
179. Narmoneva, D.A., Cheung, H.S., Wang, J.Y., Howell, D.S., Setton, L.A. Altered swelling behavior of femoral cartilage following joint immobilization in a canine model. J. Orthop. Res. 20(1):83-91, Jan 2002.
180. Masse, P.G., Boskey, A.L., Ziv, I., Hauschka, P., Donovan, S.M., Howell, D.S., Cole, D.E. Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal mode. BMC Musculoskelet. Disord. 4(1):2, Feb. 20 2003.
Other Presentations, 1958-:
1. Elden, H.R., Howell, D.S. Effects of electrolytes on contraction-elongation phenomena in rat tail tendons. Gordon Conference on Bones and Teeth, Meriden, NH, 1959.
2. Elden, H., Howell, D.S. A basis for collagen apatite interaction. Fed. Proc. 19:142, 1960.
3. Elden, H.R., Howell, D.S. Collagen and hydroxyapatite interactions. Arthritis Rheum. 3:250, 1960.
4. Elden, H.R., Howell, D.S. Physical-chemical aspects of aging collagenous tissues. Tipographia Edizioni Minerva Med. 2:13, 1961.
5. Howell, D.S., Carlson, L. A biophysical study of osteoid and cartilaginous matrices during in vitro calcification. Clin. Res. 11:179, 1963.
6. Elden, H.R., Howell, D.S. Kinetic mechanisms of precipitation and their application to the calcium-phosphate system. Gordon Conference on Bones and Teeth, Meriden, NH, 1963.
7. Salzman, R., Jannach, J., Howell, D.S. Histochemical features of a fibrinolytic system in human epiphyseal cartilage. Clin. Res. 13:63, 1965.
9. Pita, J.C., Cuervo, L.A., Muller, F.J., Madruga, J.E., Howell, D.S. Role of the fast sedimenting proteinpolysaccharide present in the cartilage fluid as a regulator of mineral deposition in bone. Clin. Res. 19:77, 1971.
10. Altman, R.D., Howell, D.S., Pita, J.C., Madruga, J.F., Muller, F.J. Biochemical properties of proteinpolysaccharide complexes (PPC) in fresh human osteoarthritis cartilage. Clin. Res. 19:76, 1971.
11. Howell, D.S., Muniz, O.E., Pita, J.C., Alvarez, R.T., Altman, R.D. Distinctive pyrophosphate catabolism by rabbit and human knee articular cartilages. Clin. Res. 2l:96, 1973.
12. Dereszewski, G.N., Rubin, R.W., Blanco, L.N., Howell, D.S. Characterization of rabbit epiphyseal cartilage matrix vesicles. J. Cell Biol. 83:265A, 1979.
13. Howell, D.S., Alvarez, T.R., Alvarez, J. Regulation of cartilage calcification in organ culture: the apparent role of lysozyme. Clin. Res. 29:166A 1981.
14. Dereszewski, G., Flowers, M.E., Howell, D.S. Isolated matrix vesicle permeability. J. Dent. Res.61:#1215, 1982.
15. Howell, D.S. Effect of antiarthritic agents in preserving cartilage integrity. International Congress of Rheumatology, 16 th, Sydney, Aus., 1985. Recent Advances in Connective Tissue Research. p. 41.
16. Cieslak, S., Howell, D.S., Boyan, B. Microanalysis of phospholipids in epiphyseal cartilage extracellular fluid. Program and Abstracts of Papers. American Association for Dental Research, Washington, D.C., 1986. p. 99.
17. Howell, D.S., Muniz, O.E., Carreno, M.R., Woessner, J.F., Castiglione, G., Dean, D.D. Further evidence for collagenase production by hypertrophying chondrocytes. Trans. Ann. Meet. Orthop. Res. Soc. 12:513, 1987.
18. Howell, D.S., Dean, D.D., Carreno, M.R., Muniz, O.E. Collagenase and cell volume changes of growth cartilage in phosphonate (EHDP) induced rickets. Trans. Ann. Meet. Orthop. Res. Soc. 13:268, 1988.
19. Wu, J.J., Eyre, D.R., Dean, D.D., Howell, D.S. Quantitative studies on the collagen composition of the growth plate in the rachitic rat. Trans. Ann. Meet. Orthop. Res. Soc. 14:58, 1989.
20. Howell, D.S., Dean, D.D., Muniz, O.E., Ryan, U.S. Heparin-binding growth factors are found in hypertrophic cell zone growth cartilage. Arthritis Rheum. 32:Sl4l, 1989.
21. Myers, S., O'Connor, B., Dean, D., Brandt, K., Howell, D.S., Albrecht, M. Cartilage collagenase is increased in osteoarthritis (OA) after anterior cruciate ligament transection (ACLT) regardless of severity of synovitis. American College of Rheumatology 55th Annual Scientific Meeting, November 17-21, Boston, MA, 1991.
22. Howell, D.S., Howard, G.A., Roos, B.A. In vivo and in vitro regulation of cartilage metabolism by parathyroid hormone. J. Bone Min. Res. 8:S321, 1993.
23. Rosenwasser, M.P., Vostrejs, M., Stazzone, E.J., Saed-Nejad, F., Grande, D.P., Mow, V.C., Howell, D.S., Ratcliffe, A. Autologous bone-periosteal graft repair of osteochondral defects: a canine experimental study. Trans. Ann. Meet. Orthop. Res. Soc. 21:, 1996.
24. Djurasovic, M., Rosenwasser, M.P., Grumbles, R.M., Howell, D.S., Ratcliffe, A. Modulation of aggrecan, biglycan and decorin gene expression in the canine meniscus by joint immobilization and ACL transection. Trans. Ann. Meet. Orthop. Res. Soc. 22:440, 1997.
25. Aldridge, J.W., Grumbles, R., Rosenwasser, M.P., Howell, D.S., Ratcliffe, A. Immobilization decreases aggrecan gene expression in the canine meniscus. American Orthopedic Society for Sports Medicine, 23rd Annual Meeting, Sun Valley, Idaho, June 22-25, 1997.
26. Grumbles, R.M., Wenger, L., Agundez, A., Howell, D.S. Mechanisms of vitamin D3 regulation of vascularization in rat growth plate. Trans. Ann. Meet. Orthop. Res. Soc. 22:616, 1997.
27. Narmoneva, D.A., Wang, J.Y., Patel, S.S., Howell, D.S., Setton, L.A. Altered swelling-induced strain fields in articular cartilage following periods of immobilization. ASME Bioeng. Div. Publ. Bed. 36:125-6, 1997.
28. Guilak, F., Librizzi, N.N., Jones, W.R., Lee, G.M., Ting-Beall, H.P., Kelley, S.S., Howell, D.S., Setton, L.A. The biomechanical role of the pericellular matrix. First Smith & Nephew International Symposium, Advances in Tissue Engineering and Biomaterials, 1997.
29. Librizzi, N.N., Jones, W.R., Howell, D.S., Setton, L.A., Guilak, F. Alterations in the viscoelastic properties of the chondrocyte pericellular matrix in a canine model of joint immobiliation. Trans. Ann. Meet. Orthop. Res. Soc. 23:483, 1998.
30. Grumbles, R.M., Shao, L., Jeffrey, J.J., Howell, D.S. ILL-D stimulated collagenase-3 gene upregulation chondrocytes: suppression by pentosan polysulfate. Trans. Ann. Meet. Orthop. Res. Soc. 23:917, 1998.
31. Howell, D.S., Reuben, P., Sun, Y., Cruz, M., Wenger, L., Cheung, H.S. Mouse chondrocytes immortalized by temperature sensitive virus 40 large tumor antigen expressed multiple metalloproteinases. First International Conference on the Growth Plate, San Antonio, TX, 2001. no. 36. |
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